July 10, 2025

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Topical Treatments of 2025

Save up to 36% off

Best Choice

1

Frontline
Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

11% Off
Main highlights

Long-Lasting Protection
FRONTLINE Plus offers month-long protection against fleas, ticks, and lice with waterproof, fast-acting formula.

Ideal for Small Dogs
Perfect for dogs 5-22 lbs, ensuring safe and effective flea and tick control.

Highly Effective
Praised for consistent month-long effectiveness, even in challenging environments.
Key specs
- Target Weight:5 pounds or more
- Active Ingredients:fipronil, S-methoprene
- Application Method:topical
- Waterproof:Yes
- Treatment Duration:30 days
9.7

Exceptional

Our Rating

8.2
Simple to take off

8.0
Simple to use

8.0
Aroma
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Value for Money

2

Frontline
FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 3 Doses (Purple Box)

11% Off
Main highlights

Comprehensive Flea and Tick Protection
FRONTLINE Plus kills fleas, ticks, larvae, and lice effectively.

Ideal for Large Dogs
Perfect for dogs 45 to 88 lbs., including thick coats.

Waterproof and Long-lasting
Proven waterproof even through creeks and rivers.
9.4

Excellent

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort
3

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 6 Count (Previously Solimo)
Main highlights

Quick Flea and Tick Elimination
Starts eliminating fleas and ticks within 24 hours with up to 30 days protection.

Ideal for Small Dogs
Perfect for small dogs weighing 5-22 pounds, providing effective pest control.

Cost-Effective Alternative
Praised for being as effective as high-cost brands like Frontline.
9.3

Excellent

Our Rating

9.9
Precision

8.0
Simple to use

8.0
Aroma
4

PetArmor
PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)

14% Off
Main highlights

Effective Flea and Tick Protection
PetArmor Plus offers waterproof protection against fleas, ticks, and lice for up to 30 days.

Ideal for Active Dogs
Perfect for dogs 5-22 lbs who frequently go outdoors.

Highly Praised Long-Lasting Formula
Customers appreciate its ability to break the flea cycle and provide lasting protection.
9.2

Excellent

Our Rating

9.3
Water tight

8.2
Simple to use

8.0
Aroma
5

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 6 Count (Previously Solimo)
Main highlights

Key Features
Eliminates fleas, ticks within 24 hours, prevents infestations, waterproof, provides 30 days protection. Active ingredients: Fipronil, s-methoprene.

Ideal Use Cases
Perfect for medium dogs (23-44 pounds) engaging in water activities or exposed to wet conditions, ensuring continuous protection.

Customer Reviews Summary
Highly praised for its effectiveness in flea and tick prevention and the convenience of a 30-day protection period.
9.1

Excellent

Our Rating

9.9
Precision

8.2
Simple to use

8.0
Comfort
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6

Amazon Basics
Amazon Basics Flea, Tick & Mosquito Topical Treatment for Large Dogs (21-55 pounds), 6 Count (Previously Solimo)

36% Off
Main highlights

Fast Acting Protection
Starts eliminating fleas and ticks within 24 hours, providing up to 30 days of protection.

Ideal for Prevention
Best used consistently monthly to prevent flea infestations in large dogs.

Cost Effective Solution
Praised for affordability compared to other flea and tick treatments.
Key specs
- Target Weight:21-55 pounds
- Active Ingredients:FiImidacloprid, Permethrin, Pyriproxyfen
- Application Method:Topical
- Waterproof:24 hours after application
- Treatment Duration:Up to 30 days
9.0

Excellent

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Long life
7

TevraPet
TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment
Main highlights

Fast Acting Flea and Tick Protection
Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen for quick and effective pest control.

Ideal for Large Dogs
Perfect for extra-large dogs 55+ lbs needing monthly flea and tick prevention.

Easy Application Praised by Users
Customers appreciate the simple application process and effective pest prevention.
8.9

Very Good

Our Rating

8.2
Simple to use

8.0
worth the money

8.0
Aroma
8

Amazon Basics
Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 6 Count (Previously Solimo)

10% Off
Main highlights

Fast-Acting Protection
Begins eliminating fleas and ticks within 24 hours.

Ideal for Multi-Cat Households
Provides six doses, perfect for homes with multiple cats.

High Customer Satisfaction
Praised for affordability and effectiveness in eliminating fleas.
8.7

Very Good

Our Rating

8.0
Simple to use

8.0
Aroma

8.0
Comfort
9

Advecta
Advecta Ultra Flea And Tick Prevention For Dogs - Dog and Puppy Treatment and Control - Mosquito Repellent - Medium, Fast Acting Waterproof Topical Drops, 4 Month Supply

16% Off
Main highlights

Breaks Flea Life Cycle Effectively
BREAK THE FLEA LIFE CYCLE: Effectively breaks the flea life-cycle by killing all life stages of fleas: adults, eggs and larvae.

Best for Flea-Infested Areas
Ideal for use in regions with tough flea infestations, such as Florida, and for dogs prone to allergies and skin problems.

Highly Praised Cost-Effectiveness
Customers appreciate the product's cost-effectiveness, as it provides similar protection as higher-priced brands at a more affordable price.
8.5

Good

Our Rating

8.4
Simple to use

8.0
Aroma

8.0
Comfort
10

Frontline
Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments

11% Off
Main highlights

Comprehensive Flea and Tick Protection
FRONTLINE Plus for Dogs offers fast-acting, waterproof protection against fleas, ticks, and lice for a full 30 days.

Ideal for Large Dogs
Specially designed for dogs weighing 89 to 132 lbs, ensuring optimal protection and dosage.

Highly Praised Ease of Use
Customers appreciate the simple, topical application method that avoids the need for pills.
8.4

Good

Our Rating

8.7
Simple to use

8.0
Precision

8.0
worth the money

Topical Treatments of 2025

1

Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

8.2

8.0

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 3 Doses (Purple Box)

8.0

8.0

8.0

3

Amazon Basics Flea and Tick Topical Treatment for Small Dogs (5-22 pounds), 6 Count (Previously Solimo)

9.9

8.0

8.0

4

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 3 Doses, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs)

9.3

8.2

8.0

5

Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 6 Count (Previously Solimo)

9.9

8.2

8.0

6

Amazon Basics Flea, Tick & Mosquito Topical Treatment for Large Dogs (21-55 pounds), 6 Count (Previously Solimo)

8.0

8.0

8.0

7

TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment

8.2

8.0

8.0

8

Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 6 Count (Previously Solimo)

8.0

8.0

8.0

9

Advecta Ultra Flea And Tick Prevention For Dogs - Dog and Puppy Treatment and Control - Mosquito Repellent - Medium, Fast Acting Waterproof Topical Drops, 4 Month Supply

8.4

8.0

8.0

10

Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments

8.7

8.0

8.0

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Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), 3 Count (Previously Solimo)

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Amazon Basics Flea and Tick Topical Treatment for X-Large Dogs (89-132 Pounds), 3 Count (Previously Solimo)

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Amazon Basics Flea and Tick Topical Treatment for Medium Dogs (23-44 Pounds), 3 Count (Previously Solimo)

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