Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
Advertising Disclosure
Ergonomic Gaming Mice of 2025
Save up to 42% off
- Home
- Electronics
- Computers & accessories
- Computer accessories & peripherals
- Keyboards, mice & accessories
- Mice
-
How do we rank?
Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like youCareful review Our team ensures quality, value, and fit based on real user feedbackTrusted insights AI and human analysis guide your decisions, reflecting real user prioritiesReal users impactThousands of users trust our site daily
Based on millions of stores and reviews
Shoppers influence our rankings
Analyzing top stores
- Value for Money
2
ASUSASUS ROG Spatha X Wireless Gaming Mouse (Magnetic Charging Stand, 12 Programmable Buttons, 19,000 DPI, Push-fit Hot Swap Switch Sockets, ROG Micro Switches&Paracord and Aura RGB lighting),Black
30% OffMain highlights-
Dual-mode Connectivity Feature
-
Ideal for Competitive Gaming
-
Praised Customization and Comfort
-
3
RazerRazer Basilisk V3 Customizable Ergonomic Gaming Mouse: Fastest Gaming Mouse Switch - Chroma RGB Lighting - 26K DPI Optical Sensor - 11 Programmable Buttons - HyperScroll Tilt Wheel - Classic Black
42% OffMain highlights-
Ergonomic Design with Thumb Rest
-
Versatile Gaming and Office Use
-
Praised Hyperscroll Tilt Wheel
-
4
RedragonRedragon M908 Impact RGB LED MMO Gaming Mouse with 12 Side Buttons, Optical Wired Ergonomic Mouse with Max 12,400DPI, High Precision, 18 Programmable Macro Shortcuts, Comfort Grip
30% OffMain highlights-
High Precision and Customization
-
Ideal for MMO Gaming
-
Highly Praised Comfort
-
5
ProtoArcProtoArc Ergonomic Mouse, EM11 NL Bluetooth Rechargeable Wireless Vertical Mouse, 3 Multi-Device Connectivity for Computer/PC/Laptop, 2.4GHz Optical Mice for Windows, Mac OS, Black
29% OffMain highlights-
Ergonomic Design Benefit
-
Multi-Device Usability
-
Customer Praised Comfort
-
-
See Today’s Deals & Prices
6
LogitechLogitech Lift Vertical Ergonomic Mouse, Wireless Bluetooth or USB Receiver, Quiet Clicks, 4 Buttons, Right Hand Wireless Mouse, Windows/macOS/iPadOS, Laptop, PC - Graphite
Main highlights-
Ergonomic Comfort
-
Versatile Connectivity
-
Quiet Clicks
-
7
RazerRazer Basilisk V3 X HyperSpeed Customizable Wireless Gaming Mouse: Mechanical Switches Gen-2-5G Advanced 18K Optical Sensor - Chroma RGB 9 Programmable Controls 535 Hr Battery Classic Black
35% OffMain highlights-
Ergonomic Design with Custom Controls
-
Ideal for Long Gaming Sessions
-
Praised for Smooth Performance
-
8
RedragonRedragon M811 Aatrox MMO Gaming Mouse, 15 Programmable Buttons Wired RGB Mouse w/Ergonomic Natural Grip Build, 10 Side Macro Keys, Software Supports DIY Keybinds & Backlit
Main highlights-
Customizable DPI and Button Options
-
Ideal for MMO Gamers
-
Praised Button Layout
-
9
Logitech GLogitech G502 HERO High Performance Wired Gaming Mouse, HERO 25K Sensor, 25,600 DPI, RGB, Adjustable Weights, 11 Programmable Buttons, On-Board Memory, PC / Mac
36% OffMain highlights-
Advanced Sensor Technology
-
Versatile Gaming and Productivity
-
Customizable Weight System
-
10
LogitechLogitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite
17% OffMain highlights-
Ergonomic Design Benefit
-
Ideal for Multi-Device Use
-
Praised for Comfort
-
Similar products on Amazon
- 10% OffFree Shipping
Nulea M504 Wired Vertical Mouse, USB Ergonomic Optical Mouse with 4 Adjustable DPI, 11 RGB Backlight Modes, Compatible for Laptop, PC, Desktop, Mac, Grey
Advanced Ergonomic Design: Designed as 57 degree natural grip and keep your forearm muscle under natural position, making movement smoother and more flexible, reducing arm discomfort and effectively relieving wrist pain. Compared with traditional mouse, with unique ergonomic vertical mouse design, it may take a few days to get used to using it.$17.99
$19.99 (10% Off) - 17% OffFree Shipping
Redragon M602 Gaming Mouse, Ergonomic RGB Gaming Mouse Wired with 7200 Adjustable DPI, 9 Programmable Buttons, Professional Software for Gamer Office [Black]
【Classics Last Longer】Redragon Gaming Mouse - M602 was launched in 2015, It is Professional and Durable with a positive rating of 96.8%, a quality product with historical verification.$19.99
$24.31 (17% Off) - Free Shipping
TRELC Gaming Mouse with 5 D Rocker, Ergonomic Mouse with 10000 DPI/11 Programmable Buttons, Vertical Gaming Mice Wired for PC/Laptop/E-Sports/Gamer (Black)
【Ergonomic Vertical Mouse】This vertical mouse bases on ergonomics, effectively reducing user’s wrist strain and muscle pain by a natural handshake griping way. An optimal healer for wrist pain, shoulder fatigue, Carpal Tunnel Syndrome and tendinitis.$28.99
- Free Shipping
Perixx PERIMICE-713RX Wireless Rechargeable Vertical Mouse - Duo Wired and Wireless Charging Feature - Charging Pad Included - 6 Buttons Design - Black - Right-Handed Design
DUAL RECHARGEABLE OPTIONS - Experience ultimate convenience with dual charging capabilities. The Perixx PERIMICE-713RX offers both wired charging via a USB-C connection and wireless charging for added flexibility (wireless charging pad included). The package also includes a USB-C to A cable for easy wired charging.$34.99
- 30% OffFree Shipping
Redragon Wireless Gaming Mouse, Ergonomic Mouse 16000 DPI with Rapid Fire Key, 9 Macro Buttons, 170-Hour Durable Power Capacity and RGB Backlight Wired/Wireless Mouse for Laptop/Mac/PC
WIRELESS FOR BOUNDLESS WINNING: Redragon wireless gaming mouse with 2.4Ghz nano receiver offers you the purest mouse moving experience and hype your KDA rise again. The rechargeable wireless mouse has a battery life between 13 hours (RGB on) and 170 hours (RGB off) on a single charge$31.99
$45.99 (30% Off) - Free Shipping
Redragon M612 Predator RGB Gaming Mouse, 8000 DPI Wired Optical Mouse with 11 Programmable Buttons & 5 Backlit Modes, Software Supports DIY Keybinds Rapid Fire Button
Pentakill, 5 DPI Levels - Geared with 5 redefinable DPI levels (default as: 500/1000/2000/3000/4000), easy to switch between different game needs. Dedicated demand of DPI options between 500-8000 is also available to be processed by software.$19.99
- Free Shipping
Anker Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons CE100
Ultimate Comfort: Embrace the comfort of Anker's Ergonomic Mouse, scientifically designed to encourage healthy neutral "handshake" wrist and arm positions. This wired mouse ensures smoother movement and significantly less strain, making it an ideal choice for extended computer use.$25.99
- Free Shipping
J-Tech Digital Ergonomic Mouse with Wireless Connection, Removable Palm Rest, Thumb Buttons, Rechargeable Battery, 800 DPI, Compatible with Windows and MAC OS
Ergonomic Wireless Design: The J-Tech Digital V638’s comfortable, ergonomic “handshake” design greatly reduces arm/wrist/hand strain while providing relief for carpal tunnel syndrome. Back/forward thumb buttons provide extra convenience. (Button functionality can also be changed or reassigned using third-party software.) Works on most non-metallic surfaces. The built-in lithium battery is fully rechargeable.$24.99
- 25% OffFree Shipping
Redragon Gaming Mouse, Wireless Mouse Gaming with 8000 DPI, PC Gaming Mice with Fire Button, RGB Backlit Programmable Ergonomic Mouse Gamer, Rechargeable, 70Hrs for Windows, Mac Gamer, Black
【Fully Programmable Gaming Mouse】- Redragon Wireless Gaming Mouse All buttons can be programmed with the driver and support macro editing. You can remap the buttons, assignment of complex macro functions, change RGB backlit effects, and adjust DPI (250-8000) to fit your different needs.$29.99
$39.99 (25% Off) - Free Shipping
MEETION Ergonomic Mouse, Wireless Vertical Mouse RGB Backlit Rechargeable Mice for Bluetooth(5.2 + 3.0) & USB-A with USB-C Adapter 4 Adjustable DPI for Mac/Windows/Andriod/PC/Tablet/iPad Black
【ERGONOMIC VERTICAL MOUSE】 BTM010 ergonomic vertical mouse is meticulously crafted with a unique vertical shape that reduces wrist and forearm strain, delivering a comfortable and natural grip. It promotes a more ergonomic posture, alleviating discomfort and enhancing overall comfort.$19.98