Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
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Computer Mouse Wired Ergonomics of 2025
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- Best Choice
1
DeLUXDeLUX Ergonomic Mouse, Wired Large RGB Vertical Mouse with 6 Buttons, 4000DPI, Removable Wrist Rest for Carpal Tunnel (M618Plus RGB-Wired)
Main highlights-
Mesmerizing RGB Lighting
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Ideal for Ergonomic Gaming
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Highly Comfortable for Large Hands
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How do we rank?
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- Value for Money
2
AnkerAnker Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons CE100
Main highlights-
Ergonomic Design for Comfort
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Ideal for Office and Gaming
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Highly Praised for Pain Relief
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4
RedragonRedragon M602 Gaming Mouse, Ergonomic RGB Gaming Mouse Wired with 7200 Adjustable DPI, 9 Programmable Buttons, Professional Software for Gamer Office [Black]
17% OffMain highlights-
High-Precision Sensor and Customizable DPI
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Ergonomic Design for Comfortable Gaming
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Highly Praised Comfort and Performance
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5
RedragonRedragon M612 Predator RGB Gaming Mouse, 8000 DPI Wired Optical Mouse with 11 Programmable Buttons & 5 Backlit Modes, Software Supports DIY Keybinds Rapid Fire Button
Main highlights-
Customizable DPI Levels
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Ideal for Gamers
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Praised Ergonomic Design
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7
NuleaNulea M504 Wired Vertical Mouse, USB Ergonomic Optical Mouse with 4 Adjustable DPI, 11 RGB Backlight Modes, Compatible for Laptop, PC, Desktop, Mac, Grey
10% OffMain highlights-
Ergonomic Design Benefits
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Ideal for Office Use
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Praised RGB Lighting
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CensprinCensprin USB Computer Mouse Wired, Silent Click Corded Mouse 3-Button Wired Optical Mouse, Office and Home Mice, Ergonomic Shape for Windows Computers, Macs, iPad, PC and Laptops
Main highlights-
Silent Click Ergonomic Design
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Ideal for Office and Home Use
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Highly Praised Quiet Operation
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PORLEIWired Trackball Mouse with RGB Lighting, Ergonomic Thumb Control to Reduce Muscle Strain, 5 Adjustable DPI Settings, Dual USB-C & USB-A Connectivity, Compatible with PC, Laptop, Mac, Windows-Blue
Main highlights-
Ergonomic Comfort Design
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Perfect for Tight Workspaces
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Great Value for Price
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Similar products on Amazon
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TECKNET USB Wired Mouse, 6-Button Corded Computer Mouse with 4 Adjustable DPI, Optical Computer Mice with Ergonomic Design and 5FT Cord for Laptop, Chromebook, PC, Desktop, Mac, Notebook-Gray
【High Precision and Durability】: TECKNET Tru-Wave technology wired computer mouse provides precise, intelligent cursor control and tracking on many surface types, even on smooth surfaces with glass. Tested for over 6 million keystrokes, the wired mouse ensures responsive clicks and a longer lifespan for daily use.$9.99
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HP Wired Mouse 100 - Precise Optical Sensor with 1600 DPI - Easy USB Connection - Ambidextrous Design - 3 Button Control & Built-in Scrolling - Multi-OS Compatible (6VY96AA#ABL)
FAST, EASY SET-UP: Convenient USB-A connectivity lets you plug-in and work—or play—right away.$9.60
- 20% OffFree Shipping
shoplease Wired Vertical Mouse, Optical Ergonomic Mouse with 4 Adjustable 800/1200/2000/3200, 5 Buttons USB Computer Mouse, Better for Large and Medium Sized Hands
【Ergonomic Design】-Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain. (Note: it is a right-handed mouse)$9.49
$11.99 (20% Off) - 41% OffFree Shipping
memzuoix Wired Mouse, USB Computer Mouse 1400 DPI Mobile Optical Mouse Ergonomic Design Computer Mice with 5FT Cord for Laptop, PC, Desktop, MacBook, 5 Buttons (Pomegranate Red)
Plug & Play Super Easy To Use: memzuoix wired computer mouse offers a seamless installation process—just plug it into your computer’s USB port and it’s ready to use instantly. No need for additional drivers or software, making setup fast and effortless.Portable design make it easy to store in bag. It's the best mouse for a gifts.$7.58
$12.99 (41% Off) - 10% OffFree Shipping
TechRise Ergonomic Mouse, Vertical Mouse with 6400 DPI, Silent Mouse Plug & Play, Optical Mouse with Forward Backward Shortcut Keys, Wired Mouse for Laptop, Computer, Desktop, PC, MacBook(White)
【Reduced Wrist Stress】TechRise ergonomic mouse is ergonomically designed to fit the natural curve of your hand and bring your palm closer to the vertical angle of the desktop, which helps to reduce arm discomfort and effectively relieves wrist pain, ideal for long hours of computer use.$8.99
$9.99 (10% Off) - Free Shipping
Micropack Ergonomic Mouse Wired for Laptop, PC Computer and Desktop, Ergo Mouse Vertical with Silent Clicks, Up to 3200 DPI Adjustable Mouse Sensitivity, Green
Ergonomic Design: The ergonomically vertical handshake position reduces muscular strain and the pressure on your wrist, while your thumb is positioned comfortably on the thumb rest.$10.99
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HXMJ- Ergonomic Vertical Mouse Wired,USB Optical Mice,Silent Click,Right Handed-Black
【 Ultimate Comfort】Embrace the comfort of our Ergonomic Mouse, scientifically designed to encourage healthy neutral "handshake" wrist and arm positions. This wired mouse ensures smoother movement and significantly less strain, making it an ideal choice for extended computer use.$16.99
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shoplease Wired Ergonomic Mouse, Optical Vertical Mouse with 3 Adjustable 800/1200/1600, 6 Buttons USB Computer Mouse
【Ergonomic Design】-Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain. (Note: it is a right-handed mouse)$9.49
$9.99 - Free Shipping
ONITOON Wired USB Mouse, Computer Mouse with RGB Lighting, 4 Adjustable DPI, Ergonomic Optical Office Mouse, 7 Buttons Corded Mice for Window/PC/Laptop/Desktop/Mac/Chromebook, White
【Cool RGB Lighting】When the wired usb mouse is plugged into the device, gradient dynamic RGB light will light up to enhance the ambience and gaming experience. Press DPI- button for 3 seconds to enter low light mode.$7.99
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Logitech B100 Wired Mouse for Computer and Laptop, USB Corded Mouse, Right or Left Hand Use - Black
Side-to-side scrolling Plus zoom lets you instantly zoom in or out and scroll. Suitable for working with spreadsheets and presentations. This logitech wired mouse works well as a computer mouse.$7.99