Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
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Computer Mice Ergonomics of 2025
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LogitechLogitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite
16% OffMain highlights-
Ergonomic Design Benefit
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Ideal for Multi-Device Use
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Praised for Comfort
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How do we rank?
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- Value for Money
2
LogitechLogitech Lift Vertical Ergonomic Mouse, Wireless Bluetooth or USB Receiver, Quiet Clicks, 4 Buttons, Right Hand Wireless Mouse, Windows/macOS/iPadOS, Laptop, PC - Graphite
Main highlights-
Ergonomic Comfort
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Versatile Connectivity
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Quiet Clicks
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3
AnkerAnker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600DPI, 5 Buttons - Black
Main highlights-
Ergonomic Design for Comfort
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Ideal for Office and Home Use
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Praised for Wrist Pain Relief
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4
LogitechLogitech M575 Ergonomic Wireless Trackball USB Mouse, Black (910-005869)
21% OffMain highlights-
Ergonomic_Design_and_Comfort
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Ideal_for_Stationary_Use
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Praised_Trackball_Feature
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5
ProtoArcProtoArc Ergonomic Mouse, EM11 NL Bluetooth Rechargeable Wireless Vertical Mouse, 3 Multi-Device Connectivity for Computer/PC/Laptop, 2.4GHz Optical Mice for Windows, Mac OS, Black
Main highlights-
Ergonomic Design Benefit
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Multi-Device Usability
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Customer Praised Comfort
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See Today’s Deals & Prices
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TECKNETTECKNET Ergonomic Mouse, Wireless Bluetooth Vertical Mouse, 4800 DPI Optical Tracking, 6 Adjustable DPI, Quiet Clicks, 2.4GHz with USB A Receiver, 6 Buttons, Wide Compatibility - Black
10% OffMain highlights-
Seamless Device Connectivity
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Ideal for Office Use
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Ergonomic Comfort
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TECKNETTECKNET Ergonomic Mouse Wireless, Rechargeable Mouse Wireless Silent for Carpal Tunnel Right Hand, 2.4GHz USB Vertical Mouse Wireless for Laptop, 5 Adjustable 4800 DPI, Computer, MacBook, Desktop
Main highlights-
Ergonomic Design
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Ideal for Quiet Spaces
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Rechargeable Battery Life
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8
AnkerAnker Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons CE100
Main highlights-
Ergonomic Design for Comfort
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Ideal for Office and Gaming
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Highly Praised for Pain Relief
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9
POJTKPOJTK Ergonomic Wireless Rechargeable Mouse, Bluetooth+USB A+Type C(3 in 1) Connection, 5 Levels Up to 4800 DPI, 6 Silent Buttons, 2.4GHz Carpal Tunnel Vertical Mice, for Laptop, Desktop,MacBook-black
Main highlights-
Ergonomic Design and Comfort
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Versatile Connectivity Options
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Silent Operation
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10
NuleaNulea M501 Wireless Trackball Mouse, Rechargeable Ergonomic, Easy Thumb Control, Precise & Smooth Tracking, 3 Device Connection (Bluetooth or USB Receiver), Compatible for PC, Laptop, Mac, Windows.
Main highlights-
Ergonomic Design for Comfort
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Ideal for Compact Spaces
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Reliable Wireless Connection
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Similar products on Amazon
- 37% OffFree Shipping
TECKNET Wireless Mouse, 2.4G Ergonomic Optical Mouse, Computer Mouse for Laptop, PC, Computer, Chromebook, Notebook, 6 Buttons, 24 Months Battery Life, 2600 DPI, 5 Adjustment Levels
Compact Design, Travel Friendly - With the dimension of 4.09*2.68*1.49 in, this compact mouse provides more portability and a better travel experience. Only compatible with USB-A Port Devices.$9.99
$15.99 (37% Off) - 20% OffFree Shipping
Lekvey Ergonomic Mouse, Vertical Wireless Mouse, Rechargeable 2.4G Optical Carpal Tunnel Mice: 800/1200 / 1600 DPI, 6 Buttons, for Laptop, PC, Computer, Desktop, Notebook etc, Green Purple
Ergonomic, Sleek, and Trendy Colors Design: Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain. This could be your choice if you want an ergonomic, colorful mouse; Also, the various color options and the vertical design make it the ultimate choice for home, office, libraries, dormitories, high-speed rail, airplanes, or traveling use$19.99
$24.99 (20% Off) - Free Shipping
Amazon Basics Computer Mouse Wireless, Ergonomic, 2.4 GHz Optical, DPI Adjustable, Compatible With PC, Mac, Laptop, Black
COMFORTABLE NAVIGATION: The wireless mouse is designed for smooth and easy computer interface navigation, and provides ease of use for prolonged periods without strain$10.45
$11.58 - Free Shipping
JYKEYMOUT Bluetooth and 2.4G (2-in-1) Rechargeable Wireless Mouse, Ergonomic Vertical Design, 1000/1200/1600 DPI, 6 Silent Buttons, for Laptop, Computer, PC, MacBook, Chromebook-Black
【2-in-1 (Bluetooth & 2.4G) Dual Mode】The wireless PC mouse features both Bluetooth (5.2/3.0) and 2.4GHz USB modes. Opt for Bluetooth mode to connect to a laptop or tablet, saving a USB-A port. Especially convenient for MacBook Pro without USB port. Or choose the 2.4GHz USB mode, simply plug in the USB receiver for quick connection without the pairing process. Effortlessly switch between the two modes with the press of a button for flexible use according to your needs.$9.99
- 55% OffFree Shipping
Lekvey Ergonomic Mouse, Vertical Wireless Mouse - Rechargeable 2.4GHz Optical Vertical Mice : 3 Adjustable DPI 800/1200/1600 Levels 6 Buttons, for Laptop, PC, Computer, Desktop, Notebook etc, Black
Ergonomic, Sleek and Rechargeable Design: Scientific ergonomic design encourages healthy neutral " handshake " wrist and arm positions for smoother movement and less overall strain$17.98
$39.99 (55% Off) - 57% OffFree Shipping
Lekvey Ergonomic Mouse, Vertical Wireless Mouse: Rechargeable Optical Carpal Tunnel Mice with 2.4G USB Receiver, 1000/1200 / 1600 DPI, 6 Buttons, for Laptop, Computer, PC, Desktop, Notebook, Black
Ergonomic Mouse, Vertical Sleek Design: Experience natural fatigue relief and pain-free comfort. This cool wireless ergonomic mouse encourages a healthy, natural handshake grip, providing support for your forearm and wrist to minimize carpal tunnel strain and discomfort compared to standard mice. It is ideal for office workers, designers, travelers, and anyone in search of an all-day comfortable mouse. Relax your palm and enjoy a seamless, pain-free workflow$16.99
$39.99 (57% Off) - Free Shipping
Ergonomic Wireless Mouse with USB Receiver for PC Computer, Laptop and Desktop, Ergo Vertical Mouse with Silent Clicks Long Battery Life, Up to 1600 DPI & 1 AA Battery Powered, Green
Why we reduce its size? Since the ergo mouse was launched we always recieved feedback like "too big" "not for my hands" "large for me" from our buyers. After long discussion we decide to size down the mouse. We are listening to the voice of our customer, if you have any feedback about the new updates please contact us on Amazon. Note: Unless stated in the title, products still are old version (old size).$14.88
- 16% OffFree Shipping
TECKNET Wireless Mouse (BT5.0/3.0 & 2.4G) Rechargeable 4800 DPI Silent USB A & Bluetooth Mouse 6 Buttons, Wide Compatibility - Grey
Dual Device Connection: Connect two devices simultaneously using either Bluetooth(3.0/5.0) or USB A connection for a wireless mouse experience. Seamlessly switch between the connected devices with a simple slide of the switch button. This makes it an ideal choice for those seeking both a usb mouse and a bluetooth mouse. (PLEASE NOTE: The mouse is better suited for SMALL to MEDIUM-sized hands. However, if you have larger hands yet enjoy a smaller mouse, you might also like this one.)$19.99
$23.99 (16% Off) - Free Shipping
TECKNET USB Wired Mouse, 6-Button Corded Computer Mouse with 4 Adjustable DPI, Optical Computer Mice with Ergonomic Design and 5FT Cord for Laptop, Chromebook, PC, Desktop, Mac, Notebook-Gray
【High Precision and Durability】: TECKNET Tru-Wave technology wired computer mouse provides precise, intelligent cursor control and tracking on many surface types, even on smooth surfaces with glass. Tested for over 6 million keystrokes, the wired mouse ensures responsive clicks and a longer lifespan for daily use.$9.99
- Free Shipping
TECKNET Ergonomic Mouse, Rechargeable 2.4G+Bluetooth Vertical Mice 6 DPI Adjustable, Wireless Optical Carpal Tunnel Mouse for Right Hand, Silent 6 Buttons for Laptop, PC, MacBook, iPad - Black
USB A + BLUETOOTH MULTI DEVICE MOUSE: Ergonomic mouse with 3 modes of connection (BT5.0 + BT3.0 + 2.4GHz). Easily switch between 3 devices via the toggle button. Efficiently multitask between laptops, tablets and desktops$27.99