Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
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Optical Mouse Verticals of 2025
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AnkerAnker 2.4G Wireless Vertical Ergonomic Optical Mouse for Work, Multi-Device Connectivity, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black
Main highlights-
Ergonomic Design for Comfort
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Ideal for Office and Home Use
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Praised for Wrist Pain Relief
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How do we rank?
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3
AnkerAnker Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons CE100
Main highlights-
Ergonomic Design for Comfort
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Ideal for Office and Gaming
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Highly Praised for Pain Relief
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4
LekveyLekvey Ergonomic Mouse, Vertical Wireless Mouse - Rechargeable 2.4GHz Optical Vertical Mice : 3 Adjustable DPI 800/1200/1600 Levels 6 Buttons, for Laptop, PC, Computer, Desktop, Notebook etc, Black
37% OffMain highlights-
Ergonomic Design for Comfort
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Ideal for Long Computer Sessions
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Praised Customer Service
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5
NuleaNulea M504 Wired Vertical Mouse, USB Ergonomic Optical Mouse with 4 Adjustable DPI, 11 RGB Backlight Modes, Compatible for Laptop, PC, Desktop, Mac, Grey
10% OffMain highlights-
Ergonomic Design Benefits
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Ideal for Office Use
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Praised RGB Lighting
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TECKNETTECKNET Ergonomic Mouse, Rechargeable 2.4G+Bluetooth Vertical Mice 6 DPI Adjustable, Wireless Optical Carpal Tunnel Mouse for Right Hand, Silent 6 Buttons for Laptop, PC, MacBook, iPad - Black
21% OffMain highlights-
Simultaneous Device Connection
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Ergonomic Comfort for Arm Protection
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Customer Favorite Feature - Ergonomic Design
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PryRoseWireless Vertical Mouse, Ergonomic Wireless Mouse 2.4G High Precision Optical Mice, Reduce Wrist Pain (for Small Hands)
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Key Features
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Ideal Use Cases
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Customer Praise
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Similar products on Amazon
- 64% OffFree Shipping
memzuoix Wireless Ergonomic Mouse,Upgraded 2.4G Optical Cordless Mice with 800/1200/1600 DPI,Vertical Computer Wireless Mouse for Laptop,Mac,PC,Desktop (for Right Hand,Large),Black Mouse
Ergonomic mouse for your right hand: The wireless mouse with upgraded optical ergonomic and friendly design keeps your hand and arm staying more naturally. The ergonomic shape encourages healthy neutral "handshake" wrist and arm positions. Effectively smoother movement and less overall strain,compared with a regular wireless mouse.(The forward/back buttons are not compatible with Mac OS)$8.99
$24.99 (64% Off) - 19% OffFree Shipping
Logitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite
Pointing Device Connectivity Technology: Cable/Wireless$97.12
$119.99 (19% Off) - 16% OffFree Shipping
shoplease Wired Vertical Mouse, Optical Ergonomic Mouse with 4 Adjustable 800/1200/2000/3200, 5 Buttons USB Computer Mouse, Better for Large and Medium Sized Hands
【Ergonomic Design】-Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain. (Note: it is a right-handed mouse)$9.99
$11.99 (16% Off) - 26% OffFree Shipping
SUNGI Ergonomic Wireless Mouse,Vertical Mouse 2.4GHz Optical Mice with Adjustable DPI for Carpal Tunnel Right Hand,Black
【Ergonomic Vertical Design】Encourage healthy natural “handshake” wrist and palm position for the most comfortable grip, less wrist strain. The ergonomically- designed thumb rests and grips fit the contour of your palm for maximum comfort, perfect for small hands.The surface of the mouse is sprayed with rubber oil, which is very comfortable to touch.This mouse is very suitable for people with RSI or customers who use the mouse for a long time.$9.99
$13.59 (26% Off) - Free Shipping
TechRise Ergonomic Mouse, Vertical Mouse with 6400 DPI, Silent Mouse Plug & Play, Optical Mouse with Forward Backward Shortcut Keys, Wired Mouse for Laptop, Computer, Desktop, PC, MacBook(Gray)
【Reduced Wrist Stress】TechRise ergonomic mouse is ergonomically designed to fit the natural curve of your hand and bring your palm closer to the vertical angle of the desktop, which helps to reduce arm discomfort and effectively relieves wrist pain, ideal for long hours of computer use.$8.99
- 30% OffFree Shipping
Vassink Wireless Mouse Ergonomic Mouse Rechargeable Vertical Optical Mice with USB Receiver, 6 Buttons 2.4GHz for PC Computer,Laptop,etc(Black)
★【Ergonomic-Wireless Mouse】The design of the vertical wireless ergonomic mouse fits the size and contour of the palm, reducing the pressure on the palm and making your wireless mouse control more comfortable and natural.$13.99
$19.99 (30% Off) - Free Shipping
TECKNET Mini Vertical Wireless Mouse, Ergonomic Mouse for Small Hands, 4800DPI, 5 Adjustable DPI Levels, 6 Buttons, 2.4GHz Silent Optical Wireless Mouse for Laptop, Computers, PCs, Macs
Perfect for Small Hands: TECKNET ergonomic wireless mouse specifically designed for small to medium right hands, this vertical mouse measures 2.6 x 3.2 x 2.6 inches (6.6 x 8.1 x 6.6 cm). For an optimal fit, we recommend measuring your hand before purchasing (refer to the product images for guidance)$19.99
- 10% OffFree Shipping
TechRise Ergonomic Mouse, 2.4GHz Optical Vertical Mouse with 5 Adjustable DPI Levels, Up to 4800 DPI, Silent Wireless Mouse with 6 Ergonomic Buttons for Laptop, Desktop, PC, MacBook - Gray
【Ergonomic Design】The scientific ergonomic design positions your palm at a near-vertical angle to the desktop, promoting smoother movement and reducing overall hand and wrist stress. This wireless mouse also features convenient next/previous buttons for effortless web browsing, making it ideal for Internet surfers, gamers, and those who work for extended periods at the computer.$8.99
$9.99 (10% Off) - Free Shipping
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black (Renewed)
Scientific ergonomic design encourages healthy neutral IncheshandshakeInches wrist and arm positions for smoother movement and less overall strain.
$23.99
- Free Shipping
shoplease Wired Ergonomic Mouse, Optical Vertical Mouse with 3 Adjustable 800/1200/1600, 6 Buttons USB Computer Mouse
【Ergonomic Design】-Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain. (Note: it is a right-handed mouse)$9.49
$9.99