Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
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Medicines of 2025
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- Best Choice
1
VicksVICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps
Main highlights-
Powerful 9-Symptom Relief
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Day and Night Use
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Quick Symptom Relief
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- Value for Money
2
BenadrylBenadryl Ultratabs Allergy Relief Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Relief of Cold & Allergy Symptoms Like Sneezing, Runny Nose, & Itchy Eyes & Throat, 100 ct
24% OffMain highlights-
Powerful Allergy Relief
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Ideal for Seasonal Allergies
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Highly Effective
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3
neosporinNeosporin Original First Aid Antibiotic Ointment with Bacitracin Zinc for Infection Protection, Wound Care Treatment & Scar Appearance Minimizer for Minor Cuts, Scrapes and Burns,.5 oz
27% OffMain highlights-
24-Hour Infection Protection
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Ideal for Minor Wounds
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Highly Praised for Effectiveness
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4
TylenolTylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct
24% OffMain highlights-
Fast Acting Relief
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Ideal for Adults and Teens
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Highly Praised Effectiveness
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5
SudafedSudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct
20% OffMain highlights-
Fast Powerful Relief
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Ideal for Allergy Season
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Customer Praised Effectiveness
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6
ImodiumImodium A-D Diarrhea Relief Caplets with Loperamide Hydrochloride, Anti-Diarrheal Medicine to Help Control Symptoms of Diarrhea Due to Acute, Active & Traveler's Diarrhea, 24 ct.
38% OffMain highlights-
Effective Diarrhea Relief
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Ideal for On-the-Go Use
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Fast-Acting Relief
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7
DramamineDramamine All Day Less Drowsy, Motion Sickness Relief, 8 Count
33% OffMain highlights-
Long-lasting Relief
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Travel Essential
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Customer Praise for Effectiveness
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8
TylenolTylenol Cold + Flu Severe Medicine Caplets for Fever, Pain, Cough & Congestion, 24 ct.
28% OffMain highlights-
Comprehensive Symptom Relief
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Ideal for Cold and Flu
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Praised Effectiveness
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9
MucinexMucinex Fast-Max Liquid Gels for Day/Night Cold and Flu, 24 Count
32% OffMain highlights-
Multi-Symptom Relief Efficiency
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Ideal for Day and Night Use
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Quick Symptom Relief Praised
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10
MucinexMucinex Instasoothe Sore Throat Relief, Sore Throat Lozenges, Sore Throat Medicine with Hexylresorcinol, Cough Drops Alternative, 40 Elderberry & Wild Cherry Medicated Numbing Throat Drops
Main highlights-
Maximum Strength Relief
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Ideal for On-the-Go Relief
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Highly Praised Packaging
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Vicks VapoRub, Lavender Scent, Cough Suppressant, Topical Chest Rub & Analgesic Ointment, Medicated Vicks Vapors, Relief from Cough Due to Cold, Aches & Pains, 1.76oz
TOPICAL COUGH SUPPRESSANT; Clinically proven to reduce cough; Rub a thick layer of VapoRub ointment on your chest and throat for cough relief so you can breathe easier$6.47
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Vicks Sinex SEVERE Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Nasal Congestion due to Cold or Allergy, Sinus Pressure Relief, 265 Sprays x 2
Targets nasal congestion and sinus pressure at the source by reducing swelling in the sinuses$14.97
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TUMS Chewy Bites Antacid Tablets for Chewable Heartburn Relief and Acid Indigestion Relief, Assorted Berries - 60 Count
Comes in a container$9.98
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Encyclopedia of Cardiovascular Research and Medicine(Volume 1-4)
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Robitussin Adult Maximum Strength Cough + Chest Congestion DM Max (8 fl. oz. Bottle), Cough Suppressant & Expectorant, Raspberry Flavor
One 8 fl oz bottle of Robitussin Maximum Strength Cough and Chest Congestion DM Liquid, Congestion Relief and Cough Medicine, Raspberry Flavor$12.48
- 16% Off
Tylenol Cold + Flu Severe Daytime & Nighttime Liquid Cough Medicine with Acetaminophen Pain Reliever & Fever Reducer, Nasal Decongestant & Antihistamine, Value Pack, 2 ct. of 8 fl. oz
Value pack of Tylenol Cold + Flu + Cough Severe Liquid Medicine containing one 8-fluid ounce bottle of non-drowsy daytime relief medicine and one 8-fluid ounce bottle of nighttime relief medicine$12.29
$14.73 (16% Off) - Free Shipping
Amazon Basic Care Cold and Flu Relief, Daytime and Nighttime Combo Pack Softgels, Powerful Cold Medicine for Day and Night Multi-Symptom Relief, 48 Count(Pack of 1)
ACTIVE INGREDIENTS: Compare to the active ingredients in Vicks DayQuil Cold & Flu and Vicks NyQuil Cold & Flu$10.49
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Amazon Basic Care Complete Allergy Relief, Diphenhydramine HCl 25 mg, Relieves Symptoms, Antihistamine Tablets, 400 Count
ACTIVE INGREDIENT: These allergy relief tablets contain diphenhydramine HCl 25 mg, an antihistamine, which compares to the active ingredient in Benadryl Allergy Tablets$7.91
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Amazon Basic Care Daytime and Nighttime Max Strength Severe Cold and Flu Relief Medicine, Combo Pack, Liquid Medication for Day and Night, Original and Berry, 24 fl oz (Pack of 1)
ACTIVE INGREDIENTS: Compare this daytime and nighttime cold medicine to Vicks DayQuil Severe and Vicks NyQuil Severe active ingredients$12.72