Enzymatic Drain Cleaners of 2025

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Last Updated - April 25, 2025

Best Choice

1

Clicked 138 times in the last month

Bio-Clean
Bio-Clean Drain Septic 2# Can Cleans Drains- Septic Tanks - Grease Traps All Natural and 100% Guaranteed No Caustic Chemicals! Removes fats Oil and Grease, Completely Cleans Your System.

9.9 deep clean

9.5 Simple to use

8.4 Aroma

Why we love it

Environmentally friendly and safe.

Effective on various drain types.

Prevents costly plumbing repairs.
Main highlights

Natural Microbes and Enzymes
Special combination digests dead organic waste to prevent backups.

Versatile Usage
Ideal for kitchen sinks, showers, septic tanks, and more.

Customer Success Stories
Praised for eliminating clogs and improving drainage efficiency.
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9.6

Exceptional

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Value for Money

2

AmazonCommercial
AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack

9.3 Simple to use

9.1 worth the money

8.9 Odor elimination

Why we love it

Versatile for multiple surfaces.

Effectively removes tough odors.

Affordable and high-performing.
Main highlights

Powerful Enzymatic Cleaning
Breaks down complex organic proteins, pet stains, and odors on various surfaces.

Ideal for Pet Owners
Perfect for homes with pets, tackling messes on carpets, furniture, and more.

Highly Praised Odor Elimination
Customers love its ability to eliminate odors, not just mask them.
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9.5

Excellent

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3

Green Gobbler
Green Gobbler Enzyme Drain Cleaner | Controls Foul Odors & Breaks Down Grease, Paper, Fat & Oil in Sewer Lines, Septic Tanks & Grease Traps | 1 Gallon

12% Off

9.3 Simple to use

8.7 Aroma

8.7 Sheerness

Why we love it

Breaks down clogs naturally.

Safe for all plumbing systems.

Maintains fresh-smelling drains.
Main highlights

Effective_Clog_Removal
Utilizes natural enzymes to break down grease, fats, and oils efficiently.

Ideal_Use_for_Slow_Drains
Best used for slow drains and regular maintenance to prevent clogs.

Odor_Control_Praised
Highly praised for eliminating foul odors in drains and pipes.
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9.4

Excellent

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4

Green Gobbler
Green Gobbler Liquid Hair Drain Clog Remover & Cleaner, For Toilets, Sinks, Tubs - Septic Safe, 2 Pack

21% Off

9.3 Simple to use

8.4 Sheerness

8.2 Aroma

Why we love it

Dissolves tough clogs quickly.

Safe for all plumbing systems.

Eco-friendly and non-corrosive.
Main highlights

Powerful Formula
Clears clogs by dissolving hair, soap, and wipes effectively.

Versatile Use
Ideal for toilets, sinks, tubs, and septic systems.

Fast Action
Highly praised for quick results in customer reviews.
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9.2

Excellent

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5

Bioda
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

Why we love it

Eliminates odors effectively.

Versatile for multiple cleaning tasks.

Eco-friendly with natural ingredients.
Main highlights

Powerful Cleaning and Odor Control
This probiotic cleaner offers powerful cleaning and odor elimination for various surfaces, leaving a fresh lemon and sage scent.

Ideal for Pet and Household Use
Perfect for managing pet stains, odors, and maintaining household cleanliness, especially in bathrooms and kitchens.

Highly Effective Odor Elimination
Customers praise its ability to permanently eliminate tough odors, especially from pet-related incidents and organic waste.
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9.1

Excellent

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6

Bioda
Bioda Professional Strength Enzyme Drain Cleaner, Septic Safe Drain Odor Eliminator, Smell Eliminator

9.1 Simple to use

8.0 Aroma

8.0 Odor elimination

Why we love it

Prevents clogs effectively.

Safe for all plumbing systems.

Affordable compared to competitors.
Main highlights

Prevents Clogs with Enzyme Formula
Utilizes a probiotic and enzyme blend to digest organic waste, preventing clogs.

Ideal for Regular Maintenance
Best used as a preventative measure to maintain drain flow.

Praised for Cost-Effectiveness
Customers appreciate the competitive pricing compared to similar products.
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8.9

Very Good

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7

NORTHWEST ENTERPRISES
NORTHWEST ENTERPRISES Multi-Purpose Enzyme Cleaner - Household and Commercial Enzyme Cleaner, Fresh Lemon Scent (32 ounces)
Main highlights

SAFE AND FRESH CLEANING - Non-toxic and non-corrosive formula is safe for pets and kids while leaving a subtle, refreshing scent to rejuvenate your space.
ENZYME CARPET CLEANER - Neutralizes stubborn spots and lingering smells by penetrating deep into carpets and hard-to-reach areas. This carpet enzyme cleaner is perfect for keeping your home fresh and spotless!
ELIMINATE SLOW DRAINS AND UPLEASANT ODORS WITH EASE - our solution breaks down grease, fats, and other organic buildup, keeping your drains flowing freely and your home smelling fresh.
ALL-IN-ONE CLEANING SOLUTION - Tackle everything from daily spills to tough messes on carpets, hardwood floors, furniture, tile, drains, garbage cans, greasy restaurant floors, RV interiors, and more. The best enzymatic cleaner for your entire commercial workspace and home!
ADVANCED ENZYME ODOR ELIMINATOR - Breaks down organic matter like dog urine, cat urine, human urine, feces, grease, and grime at the source, providing a deep clean that restores and refreshes surfaces.
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8.8

Very Good

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8

HELIX LABORATORIES, INC.
Enzyme Drain Cleaner & Deodorizer for Sink Drain, Showers, Septic Systems, Bathroom & Kitchen - Smell Remover for Fruit Fly Garbage Disposals, Dishwasher & Washing Machines - (32oz)

8.9 Simple to use

8.0 Aroma

8.0 worth the money

Why we love it

Safe Eco friendly

Made in USA

Versatile uses
Main highlights

Key Features and Benefits
Eco-friendly, uses natural bacteria to eliminate odors and waste. Safe for drains and septic systems. Made in the USA with quality control.

Ideal Use Cases
Perfect for garbage disposals, washing machines, dishwashers, toilets, and slow drains. Ideal for deodorizing and unclogging without damaging pipes.

Customer Reviews Highlight
Most praised for its effectiveness in eliminating tough odors and clogs, offering satisfaction and value with a money-back guarantee.
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8.7

Very Good

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9

Green Gobbler
Green Gobbler Industrial Strength Grease and Hair Drain Clog Remover | Drain Cleaner Gel | Safe for Pipes, Toilets, Sinks, Tubs, Drains & Septic Systems | 1 Gallon

17% Off

Why we love it

Easily dissolves tough clogs effectively.

Safe for all plumbing and septic systems.

No harsh chemical odors.
Main highlights

Thick Gel Formula for Effective Clog Removal
Green Gobbler's industrial-strength gel clings to clogs, dissolving hair, grease, and more to keep pipes flowing smoothly.

Ideal for Multi-Fixture Clog Solutions
Perfect for toilets, sinks, showers, and tubs, effectively tackling multiple clogs across different fixtures.

Highly Praised for Versatility and Ease of Use
Customers love its versatility and user-friendly application, offering reliable results without harsh odors.
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8.6

Very Good

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10

Natural Elements
Natural Elements Enzyme Drain Cleaner | Digest Grease, Fats, and Paper Buildup in Drains, Septic Tanks, Grease Traps, Pipes (1 Gallon)

9.5 Odor elimination

9.1 Simple to use

8.7 worth the money

Why we love it

Eco-friendly and biodegradable.

Safe for all plumbing fixtures.

Reduces future maintenance needs.
Main highlights

Advanced Enzyme Formula
Attacks fat, organic waste, oil, paper, hair, and grease.

Ideal for Regular Maintenance
Effective for kitchens, bathrooms, septic systems, and commercial grease traps.

Highly Praised Eco-Friendliness
Customers appreciate its safety for family, pets, and environment.
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8.4

Good

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Enzymatic Drain Cleaners of 2025

1

Bio-Clean Drain Septic 2# Can Cleans Drains- Septic Tanks - Grease Traps All Natural and 100% Guaranteed No Caustic Chemicals! Removes fats Oil and Grease, Completely Cleans Your System.

Why we love it

2

AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack

Why we love it

3

Green Gobbler Enzyme Drain Cleaner | Controls Foul Odors & Breaks Down Grease, Paper, Fat & Oil in Sewer Lines, Septic Tanks & Grease Traps | 1 Gallon

Why we love it

4

Green Gobbler Liquid Hair Drain Clog Remover & Cleaner, For Toilets, Sinks, Tubs - Septic Safe, 2 Pack

Why we love it

5

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

Why we love it

6

Bioda Professional Strength Enzyme Drain Cleaner, Septic Safe Drain Odor Eliminator, Smell Eliminator

Why we love it

7

NORTHWEST ENTERPRISES Multi-Purpose Enzyme Cleaner - Household and Commercial Enzyme Cleaner, Fresh Lemon Scent (32 ounces)

8

Enzyme Drain Cleaner & Deodorizer for Sink Drain, Showers, Septic Systems, Bathroom & Kitchen - Smell Remover for Fruit Fly Garbage Disposals, Dishwasher & Washing Machines - (32oz)

Why we love it

9

Green Gobbler Industrial Strength Grease and Hair Drain Clog Remover | Drain Cleaner Gel | Safe for Pipes, Toilets, Sinks, Tubs, Drains & Septic Systems | 1 Gallon

Why we love it

10

Natural Elements Enzyme Drain Cleaner | Digest Grease, Fats, and Paper Buildup in Drains, Septic Tanks, Grease Traps, Pipes (1 Gallon)

Why we love it

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